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Логотип Ретатрутид (Retatrutide Triple Agonist)

Retatrutide Protocols

Retatrutide (LY3437943)Triple Agonist

Clinical guideline, titration schedule, dosages, and side effect management for obesity and T2D

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Possible Allergy Warning & Initial Administration Safety Protocol

Although allergic reactions to peptide compounds and benzyl alcohol (preservative in bacteriostatic water) are extremely rare, safety precautions must be followed upon therapy initiation:

  • Outpatient monitoring: First injections are recommended under medical supervision in an outpatient setting.
  • Allergy testing: Ideally, undergo an allergen test including a panel for peptides and benzyl alcohol prior to the first dose.

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Preparation for Retatrutide therapy (LY3437943)

Laboratory & Instrumental Checkup

Mandatory and recommended examinations to ensure maximum safety during treatment

Readiness before 1st injection:0 of 38 completed (0%)

Complete Blood Count (CBC + differential + ESR)

Complete Blood Count (CBC)

Evaluation of hemoglobin, erythrocytes, WBC differential, and ESR to rule out anemia and inflammatory processes.

Reference / Normal: Medical report
Pending
Value:complex

Glycated Hemoglobin (HbA1c)

Carbohydrate Metabolism

Assessment of average blood glucose over the past 3 months prior to starting therapy.

Reference / Normal: 4 – 6 %
Pending
Value:%

Serum Insulin

Carbohydrate Metabolism

Assessment of hyperinsulinemia and calculation of HOMA-IR insulin resistance index.

Reference / Normal: 2.6 – 24.9 mIU/L
Pending
Value:mIU/L

C-Peptide

Carbohydrate Metabolism

Evaluation of residual endogenous pancreatic insulin secretion.

Reference / Normal: 1.1 – 4.4 ng/ml
Pending
Value:ng/ml

Leptin

Carbohydrate Metabolism

Satiety and adipose hormone for evaluating leptin resistance.

Reference / Normal: 2 – 17 ng/ml
Pending
Value:ng/ml

TSH (Thyroid Stimulating Hormone)

Thyroid Panel

Thyroid screening (ruling out hypothyroidism as a cause of weight gain).

Reference / Normal: 0.4 – 4 mIU/L
Pending
Value:mIU/L

Free T3 (Triiodothyronine)

Thyroid Panel

Evaluation of active thyroid hormone regulating basal metabolic rate.

Reference / Normal: 3 – 6.8 pmol/L
Pending
Value:pmol/L

Free T4 (Thyroxine)

Thyroid Panel

Assessment of primary thyroid status hormone.

Reference / Normal: 12 – 22 pmol/L
Pending
Value:pmol/L

Anti-TPO Antibodies

Thyroid Panel

Exclusion of autoimmune thyroiditis (AIT).

Reference / Normal: 0 – 35 IU/ml
Pending
Value:IU/ml

Serum Calcitonin

Thyroid Panel

Recommended if thyroid nodules or family history of medullary thyroid carcinoma exist.

Reference / Normal: 0 – 11.5 pg/ml
Pending
Value:pg/ml

ALT (Alanine Aminotransferase)

Liver Panel

Exclusion of acute liver pathology and monitoring MASH/steatosis during weight loss.

Reference / Normal: 0 – 45 U/L
Pending
Value:U/L

AST (Aspartate Aminotransferase)

Liver Panel

Marker of liver parenchymal status and enzymatic activity.

Reference / Normal: 0 – 35 U/L
Pending
Value:U/L

Total Bilirubin

Liver Panel

Evaluation of biliary excretory liver function and ruling out Gilbert syndrome.

Reference / Normal: 3.4 – 20.5 µmol/L
Pending
Value:µmol/L

Direct Bilirubin

Liver Panel

Marker of cholestasis and bile duct patency.

Reference / Normal: 0 – 5.1 µmol/L
Pending
Value:µmol/L

Alkaline Phosphatase (ALP)

Liver Panel

Marker of bile flow and bone-mineral metabolism.

Reference / Normal: 40 – 150 U/L
Pending
Value:U/L

Total Serum Protein

Biochemistry & Protein Metabolism

Evaluation of hepatic protein-synthetic function and nutritional status.

Reference / Normal: 64 – 83 g/L
Pending
Value:g/L

Protein Electrophoresis Fractions

Biochemistry & Protein Metabolism

Evaluation of albumin and globulin fractions (alpha, beta, gamma).

Reference / Normal: Medical report
Pending
Value:complex

Lactate (Lactic Acid)

Biochemistry & Protein Metabolism

Marker of tissue respiration, aerobic metabolism, and oxidative stress.

Reference / Normal: 0.5 – 2.2 mmol/L
Pending
Value:mmol/L

Total Cholesterol (Lipid Panel)

Lipid Panel

Baseline parameter of overall circulating blood lipids.

Reference / Normal: 3 – 5.2 mmol/L
Pending
Value:mmol/L

LDL Cholesterol (Lipid Panel)

Lipid Panel

Assessment of atherogenic LDL "bad" cholesterol.

Reference / Normal: 0 – 3 mmol/L
Pending
Value:mmol/L

HDL Cholesterol (Lipid Panel)

Lipid Panel

Assessment of anti-atherogenic HDL "good" cholesterol.

Reference / Normal: 1 – 2.2 mmol/L
Pending
Value:mmol/L

Triglycerides (Lipid Panel)

Lipid Panel

Marker of lipid metabolism and metabolic syndrome.

Reference / Normal: 0 – 1.7 mmol/L
Pending
Value:mmol/L

Serum Creatinine / eGFR

Renal Function

Evaluation of renal filtration capacity prior to incretin therapy.

Reference / Normal: 60 – 115 µmol/L
Pending
Value:µmol/L

Serum Uric Acid

Renal Function

Monitoring hyperuricemia and gout risk during rapid weight reduction.

Reference / Normal: 150 – 420 µmol/L
Pending
Value:µmol/L

Serum Amylase / Lipase

Pancreas Panel

Pancreatic exocrine enzyme screening to rule out pancreatitis risk.

Reference / Normal: 13 – 60 U/L
Pending
Value:U/L

Homocysteine

Cardiovascular Risk & Inflammation

Vascular endothelial status and cardiovascular risk marker.

Reference / Normal: 5 – 12 µmol/L
Pending
Value:µmol/L

High-Sensitivity CRP (hs-CRP)

Cardiovascular Risk & Inflammation

Assessment of low-grade systemic vascular and metabolic inflammation.

Reference / Normal: 0 – 3 mg/L
Pending
Value:mg/L

Serum Iron (Free)

Iron Metabolism

Current circulating plasma iron level.

Reference / Normal: 10.7 – 30.4 µmol/L
Pending
Value:µmol/L

Ferritin

Iron Metabolism

Evaluation of tissue iron stores and exclusion of occult deficiency.

Reference / Normal: 30 – 200 mcg/L
Pending
Value:mcg/L

Transferrin

Iron Metabolism

Primary iron transport glycoprotein in circulation.

Reference / Normal: 2 – 3.6 g/L
Pending
Value:g/L

Vitamin D (25-OH Total)

Vitamins & Microelements

Key regulator of calcium-phosphate homeostasis, immunity, and insulin sensitivity.

Reference / Normal: 30 – 100 ng/ml
Pending
Value:ng/ml

Vitamin B12 (Active / Holotranscobalamin)

Vitamins & Microelements

Monitoring of hematopoiesis and nervous system integrity.

Reference / Normal: 37.5 – 150 pmol/L
Pending
Value:pmol/L

Vitamin B9 (Folate / Folic Acid)

Vitamins & Microelements

Regulator of DNA synthesis, hematopoiesis, and homocysteine metabolism.

Reference / Normal: 7 – 39.7 nmol/L
Pending
Value:nmol/L

Serum Zinc (Zn)

Vitamins & Microelements

Essential trace element for immunity, hormone synthesis, and antioxidant defense.

Reference / Normal: 10.7 – 18.4 µmol/L
Pending
Value:µmol/L

Serum Copper (Cu)

Vitamins & Microelements

Involvement in hematopoiesis, iron utilization, and enzymatic systems.

Reference / Normal: 12.6 – 24.4 µmol/L
Pending
Value:µmol/L

Allergy Panel (Peptides & Benzyl Alcohol)

Allergology & Safety

Exclusion of hypersensitivity to peptide structures and diluent vehicle (benzyl alcohol).

Reference / Normal: Medical report
Pending
Value:test

Abdominal Ultrasound

Instrumental Diagnostics

Assessment of liver, gallbladder, and pancreas; ruling out gallstones (cholelithiasis).

Reference / Normal: Medical report
Pending
Value:report

Thyroid Ultrasound

Instrumental Diagnostics

Evaluation of thyroid structure, volume, and nodules prior to starting therapy.

Reference / Normal: Medical report
Pending
Value:report
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Reference application for Retatrutide (LY3437943) administration protocols. Developed based on published clinical trial data from TRIUMPH and TRANSCEND (Eli Lilly, NEJM, Lancet 2023–2026).

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