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Interactive Glossary of Medical Terms
Clear, evidence-based explanations of key medical concepts, pharmacokinetics, incretin biology, and laboratory metrics for Retatrutide.
Peptides
(Пептиды)Peptides & HormonesOrganic substances composed of amino acid chains linked by peptide bonds.
Detailed biological and clinical explanation
Peptides act as signaling molecules in the body regulating a wide range of physiological processes from hormone secretion to tissue metabolism. Unlike proteins, they have lower molecular weight and shorter amino acid chains (typically up to 50 residues).
Clinical relevance in Retatrutide therapy
Receptor Agonist
(Агонист (Рецептора))PharmacokineticsA chemical substance that binds to a specific receptor and activates a biological response.
Drug Clearance (Cl)
(Клиренс (Препарата))PharmacokineticsL/day or mL/minVolume of blood plasma cleared of the drug per unit of time.
Elimination Half-Life
(Период полувыведения (T½))Pharmacokinetics~6 days (144 hours)Time required for plasma concentration of a drug to decrease by 50%.
Dose Titration
(Титрование дозы)Clinical ConceptsGradual, step-by-step dose escalation at fixed time intervals.
Glucagon-Like Peptide-1
(ГПП-1 (GLP-1))Peptides & HormonesGlucagon-like peptide-1, an incretin hormone secreted by intestinal L-cells.
Glucose-dependent Insulinotropic Polypeptide
(ГИП (GIP))Peptides & HormonesGlucose-dependent insulinotropic polypeptide secreted by small intestine K-cells.
Glucagon Receptor
(Рецепторы глюкагона (GCGR))Peptides & HormonesReceptors in liver and adipose tissue regulating lipolysis and energy expenditure.
Food Noise
(Пищевой шум (Food Noise))Clinical ConceptsIntrusive, constant background thoughts about food and eating unrelated to physiological hunger.
Glycated Hemoglobin
(Гликированный гемоглобин (HbA1c))Metabolism & Lab TestsNormal: 4.0 – 5.6 %A blood test reflecting average blood glucose levels over the past 3 months.
HOMA-IR Index
(Индекс HOMA-IR)Metabolism & Lab TestsNormal: < 2.7Homeostatic Model Assessment score measuring insulin resistance.
Hepatic Steatosis / MASLD
(Стеатоз печени / НАЖБП (MASLD))Metabolism & Lab TestsNormal liver fat: < 5%Excessive intrahepatic triglyceride accumulation in hepatocytes.
Bacteriostatic Water (BAC)
(Бактериостатическая вода (BAC water))Reconstitution & UsageSterile injection water containing 0.9% benzyl alcohol as a preservative.
Lyophilized Powder
(Лиофилизат)Reconstitution & UsageFreeze-dried powder produced via low-temperature vacuum dehydration.
Skin Dysesthesia / Cutaneous Allodynia
(Дизестезия кожи / Аллодиния)Clinical ConceptsAltered skin sensation presenting as heightened sensitivity, tingling, or tenderness.
Steady-State Concentration
(Равновесная концентрация (Steady-State))PharmacokineticsCondition where drug administration rate equals drug elimination rate.
Subcutaneous Injection (SC)
(Подкожное введение (п/к))Reconstitution & UsageInjection into the subcutaneous fat layer at a 90° or 45° angle.
Insulin Sensitivity
(Чувствительность к инсулину)Metabolism & Lab TestsCellular responsiveness to insulin for glucose uptake and disposal.
High-Sensitivity C-Reactive Protein (hs-CRP)
(уц-СРБ (С-реактивный белок))Metabolism & Lab TestsNormal: < 1.0 mg/LInflammatory biomarker measuring low-grade vascular and adipocyte inflammation.
Heart Rate & Hemodynamics
(ЧСС и Гемодинамика)Clinical ConceptsHR: 60-80 bpmHeart rate (pulse) and systemic blood pressure metrics.
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