| Wk 1 | Oct 21, 2026 | 2 mg | Step 1: 2 mg | 104.3 kg | -0.7% | Therapy start. First 2 mg SC dose. |
| Wk 2 | Oct 28, 2026 | 2 mg | Step 1: 2 mg | 103.7 kg | -1.2% | GI tolerability & HR monitoring. |
| Wk 3 | Nov 4, 2026 | 2 mg | Step 1: 2 mg | 103.2 kg | -1.7% | GI tolerability & HR monitoring. |
| Wk 4 | Nov 11, 2026 | 2 mg | Step 1: 2 mg | 102.7 kg | -2.2% | GI tolerability & HR monitoring. |
| Wk 5 | Nov 18, 2026 | 4 mg | Step 2: 4 mg | 102.2 kg | -2.7% | Escalation to 4 mg. Assess tolerability, HR & weight trend. |
| Wk 6 | Nov 25, 2026 | 4 mg | Step 2: 4 mg | 101.7 kg | -3.1% | GI tolerability & HR monitoring. |
| Wk 7 | Dec 2, 2026 | 4 mg | Step 2: 4 mg | 101.2 kg | -3.6% | GI tolerability & HR monitoring. |
| Wk 8 | Dec 9, 2026 | 4 mg | Step 2: 4 mg | 100.8 kg | -4% | GI tolerability & HR monitoring. |
| Wk 9 | Dec 16, 2026 | 6 mg | Step 3: 6 mg | 100.4 kg | -4.4% | Escalation to 6 mg. Assess tolerability, HR & weight trend. |
| Wk 10 | Dec 23, 2026 | 6 mg | Step 3: 6 mg | 100 kg | -4.8% | GI tolerability & HR monitoring. |
| Wk 11 | Dec 30, 2026 | 6 mg | Step 3: 6 mg | 99.5 kg | -5.2% | GI tolerability & HR monitoring. |
| Wk 12 | Jan 6, 2027 | 6 mg | Step 3: 6 mg | 99.1 kg | -5.6% | GI tolerability & HR monitoring. |
| Wk 13 | Jan 13, 2027 | 8 mg | Step 4: 8 mg | 98.7 kg | -6% | Escalation to 8 mg. Assess tolerability, HR & weight trend. |
| Wk 14 | Jan 20, 2027 | 8 mg | Step 4: 8 mg | 98.3 kg | -6.4% | GI tolerability & HR monitoring. |
| Wk 15 | Jan 27, 2027 | 8 mg | Step 4: 8 mg | 97.9 kg | -6.8% | GI tolerability & HR monitoring. |
| Wk 16 | Feb 3, 2027 | 8 mg | Step 4: 8 mg | 97.4 kg | -7.2% | GI tolerability & HR monitoring. |
| Wk 17 | Feb 10, 2027 | 10 mg | Step 5: 10 mg | 97 kg | -7.6% | Escalation to 10 mg. Assess tolerability, HR & weight trend. |
| Wk 18 | Feb 17, 2027 | 10 mg | Step 5: 10 mg | 96.6 kg | -8% | GI tolerability & HR monitoring. |
| Wk 19 | Feb 24, 2027 | 10 mg | Step 5: 10 mg | 96.3 kg | -8.3% | GI tolerability & HR monitoring. |
| Wk 20 | Mar 3, 2027 | 10 mg | Step 5: 10 mg | 95.9 kg | -8.7% | GI tolerability & HR monitoring. |
| Wk 21 | Mar 10, 2027 | 12 mg | Maintenance Dose (12 mg) | 95.4 kg | -9.1% | Reached target dose 12 mg (maximum). Hold this dose. |
| Wk 22 | Mar 17, 2027 | 12 mg | Maintenance Dose (12 mg) | 95.1 kg | -9.4% | GI tolerability & HR monitoring. |
| Wk 23 | Mar 24, 2027 | 12 mg | Maintenance Dose (12 mg) | 94.7 kg | -9.8% | GI tolerability & HR monitoring. |
| Wk 24 | Mar 31, 2027 | 12 mg | Maintenance Dose (12 mg) | 94.3 kg | -10.2% | 24-week milestone: liver fat assessment & HR check. |
| Wk 25 | Apr 7, 2027 | 12 mg | Maintenance Dose (12 mg) | 94 kg | -10.5% | GI tolerability & HR monitoring. |
| Wk 26 | Apr 14, 2027 | 12 mg | Maintenance Dose (12 mg) | 93.6 kg | -10.9% | GI tolerability & HR monitoring. |
| Wk 27 | Apr 21, 2027 | 12 mg | Maintenance Dose (12 mg) | 93.2 kg | -11.2% | GI tolerability & HR monitoring. |
| Wk 28 | Apr 28, 2027 | 12 mg | Maintenance Dose (12 mg) | 92.8 kg | -11.6% | GI tolerability & HR monitoring. |
| Wk 29 | May 5, 2027 | 12 mg | Maintenance Dose (12 mg) | 92.5 kg | -11.9% | GI tolerability & HR monitoring. |
| Wk 30 | May 12, 2027 | 12 mg | Maintenance Dose (12 mg) | 92.1 kg | -12.3% | GI tolerability & HR monitoring. |
| Wk 31 | May 19, 2027 | 12 mg | Maintenance Dose (12 mg) | 91.8 kg | -12.6% | GI tolerability & HR monitoring. |
| Wk 32 | May 26, 2027 | 12 mg | Maintenance Dose (12 mg) | 91.3 kg | -13% | GI tolerability & HR monitoring. |
| Wk 33 | Jun 2, 2027 | 12 mg | Maintenance Dose (12 mg) | 91 kg | -13.3% | GI tolerability & HR monitoring. |
| Wk 34 | Jun 9, 2027 | 12 mg | Maintenance Dose (12 mg) | 90.6 kg | -13.7% | GI tolerability & HR monitoring. |
| Wk 35 | Jun 16, 2027 | 12 mg | Maintenance Dose (12 mg) | 90.3 kg | -14% | GI tolerability & HR monitoring. |
| Wk 36 | Jun 23, 2027 | 12 mg | Maintenance Dose (12 mg) | 89.9 kg | -14.4% | GI tolerability & HR monitoring. |
| Wk 37 | Jun 30, 2027 | 12 mg | Maintenance Dose (12 mg) | 89.6 kg | -14.7% | GI tolerability & HR monitoring. |
| Wk 38 | Jul 7, 2027 | 12 mg | Maintenance Dose (12 mg) | 89.3 kg | -15% | GI tolerability & HR monitoring. |
| Wk 39 | Jul 14, 2027 | 12 mg | Maintenance Dose (12 mg) | 88.8 kg | -15.4% | GI tolerability & HR monitoring. |
| Wk 40 | Jul 21, 2027 | 12 mg | Maintenance Dose (12 mg) | 88.5 kg | -15.7% | GI tolerability & HR monitoring. |
| Wk 41 | Jul 28, 2027 | 12 mg | Maintenance Dose (12 mg) | 88.2 kg | -16% | GI tolerability & HR monitoring. |
| Wk 42 | Aug 4, 2027 | 12 mg | Maintenance Dose (12 mg) | 87.8 kg | -16.4% | GI tolerability & HR monitoring. |
| Wk 43 | Aug 11, 2027 | 12 mg | Maintenance Dose (12 mg) | 87.5 kg | -16.7% | GI tolerability & HR monitoring. |
| Wk 44 | Aug 18, 2027 | 12 mg | Maintenance Dose (12 mg) | 87.1 kg | -17% | GI tolerability & HR monitoring. |
| Wk 45 | Aug 25, 2027 | 12 mg | Maintenance Dose (12 mg) | 86.7 kg | -17.4% | GI tolerability & HR monitoring. |
| Wk 46 | Sep 1, 2027 | 12 mg | Maintenance Dose (12 mg) | 86.4 kg | -17.7% | GI tolerability & HR monitoring. |
| Wk 47 | Sep 8, 2027 | 12 mg | Maintenance Dose (12 mg) | 86.1 kg | -18% | GI tolerability & HR monitoring. |
| Wk 48 | Sep 15, 2027 | 12 mg | Maintenance Dose (12 mg) | 85.8 kg | -18.3% | GI tolerability & HR monitoring. |
| Wk 49 | Sep 22, 2027 | 12 mg | Maintenance Dose (12 mg) | 85.4 kg | -18.7% | GI tolerability & HR monitoring. |
| Wk 50 | Sep 29, 2027 | 12 mg | Maintenance Dose (12 mg) | 85.1 kg | -19% | GI tolerability & HR monitoring. |
| Wk 51 | Oct 6, 2027 | 12 mg | Maintenance Dose (12 mg) | 84.7 kg | -19.3% | GI tolerability & HR monitoring. |
| Wk 52 | Oct 13, 2027 | 12 mg | Maintenance Dose (12 mg) | 84.4 kg | -19.6% | GI tolerability & HR monitoring. |
| Wk 53 | Oct 20, 2027 | 12 mg | Maintenance Dose (12 mg) | 84.1 kg | -19.9% | GI tolerability & HR monitoring. |
| Wk 54 | Oct 27, 2027 | 12 mg | Maintenance Dose (12 mg) | 83.7 kg | -20.3% | GI tolerability & HR monitoring. |
| Wk 55 | Nov 3, 2027 | 12 mg | Maintenance Dose (12 mg) | 83.4 kg | -20.6% | GI tolerability & HR monitoring. |
| Wk 56 | Nov 10, 2027 | 12 mg | Maintenance Dose (12 mg) | 83.1 kg | -20.9% | GI tolerability & HR monitoring. |
| Wk 57 | Nov 17, 2027 | 12 mg | Maintenance Dose (12 mg) | 82.7 kg | -21.2% | GI tolerability & HR monitoring. |
| Wk 58 | Nov 24, 2027 | 12 mg | Maintenance Dose (12 mg) | 82.4 kg | -21.5% | GI tolerability & HR monitoring. |
| Wk 59 | Dec 1, 2027 | 12 mg | Maintenance Dose (12 mg) | 82.1 kg | -21.8% | GI tolerability & HR monitoring. |
| Wk 60 | Dec 8, 2027 | 12 mg | Maintenance Dose (12 mg) | 81.7 kg | -22.2% | GI tolerability & HR monitoring. |
| Wk 61 | Dec 15, 2027 | 12 mg | Maintenance Dose (12 mg) | 81.4 kg | -22.5% | GI tolerability & HR monitoring. |
| Wk 62 | Dec 22, 2027 | 12 mg | Maintenance Dose (12 mg) | 81.1 kg | -22.8% | GI tolerability & HR monitoring. |
| Wk 63 | Dec 29, 2027 | 12 mg | Maintenance Dose (12 mg) | 80.7 kg | -23.1% | GI tolerability & HR monitoring. |
| Wk 64 | Jan 5, 2028 | 12 mg | Maintenance Dose (12 mg) | 80.4 kg | -23.4% | GI tolerability & HR monitoring. |
| Wk 65 | Jan 12, 2028 | 12 mg | Maintenance Dose (12 mg) | 80.1 kg | -23.7% | GI tolerability & HR monitoring. |
| Wk 66 | Jan 19, 2028 | 12 mg | Maintenance Dose (12 mg) | 79.8 kg | -24% | GI tolerability & HR monitoring. |
| Wk 67 | Jan 26, 2028 | 12 mg | Maintenance Dose (12 mg) | 79.5 kg | -24.3% | GI tolerability & HR monitoring. |
| Wk 68 | Feb 2, 2028 | 12 mg | Maintenance Dose (12 mg) | 79.2 kg | -24.6% | GI tolerability & HR monitoring. |
| Wk 69 | Feb 9, 2028 | 12 mg | Maintenance Dose (12 mg) | 78.8 kg | -25% | GI tolerability & HR monitoring. |
| Wk 70 | Feb 16, 2028 | 12 mg | Maintenance Dose (12 mg) | 78.4 kg | -25.3% | GI tolerability & HR monitoring. |
| Wk 71 | Feb 23, 2028 | 12 mg | Maintenance Dose (12 mg) | 78.1 kg | -25.6% | GI tolerability & HR monitoring. |
| Wk 72 | Mar 1, 2028 | 12 mg | Maintenance Dose (12 mg) | 77.8 kg | -25.9% | GI tolerability & HR monitoring. |
| Wk 73 | Mar 8, 2028 | 12 mg | Maintenance Dose (12 mg) | 77.5 kg | -26.2% | GI tolerability & HR monitoring. |
| Wk 74 | Mar 15, 2028 | 12 mg | Maintenance Dose (12 mg) | 77.2 kg | -26.5% | GI tolerability & HR monitoring. |
| Wk 75 | Mar 22, 2028 | 12 mg | Maintenance Dose (12 mg) | 76.9 kg | -26.8% | GI tolerability & HR monitoring. |
| Wk 76 | Mar 29, 2028 | 12 mg | Maintenance Dose (12 mg) | 76.5 kg | -27.1% | GI tolerability & HR monitoring. |
| Wk 77 | Apr 5, 2028 | 12 mg | Maintenance Dose (12 mg) | 76.2 kg | -27.4% | GI tolerability & HR monitoring. |
| Wk 78 | Apr 12, 2028 | 12 mg | Maintenance Dose (12 mg) | 75.9 kg | -27.7% | GI tolerability & HR monitoring. |
| Wk 79 | Apr 19, 2028 | 12 mg | Maintenance Dose (12 mg) | 75.6 kg | -28% | GI tolerability & HR monitoring. |
| Wk 80 | Apr 26, 2028 | 12 mg | Maintenance Dose (12 mg) | 75.3 kg | -28.3% | Week 80: end of the main TRIUMPH-1 period, weight plateau expected. |
| Wk 81 | May 3, 2028 | 12 mg | Maintenance Dose (12 mg) | 75.2 kg | -28.4% | GI tolerability & HR monitoring. |
| Wk 82 | May 10, 2028 | 12 mg | Maintenance Dose (12 mg) | 75.1 kg | -28.5% | GI tolerability & HR monitoring. |
| Wk 83 | May 17, 2028 | 12 mg | Maintenance Dose (12 mg) | 75.1 kg | -28.5% | GI tolerability & HR monitoring. |
| Wk 84 | May 24, 2028 | 12 mg | Maintenance Dose (12 mg) | 75 kg | -28.6% | GI tolerability & HR monitoring. |
| Wk 85 | May 31, 2028 | 12 mg | Maintenance Dose (12 mg) | 74.9 kg | -28.7% | GI tolerability & HR monitoring. |
| Wk 86 | Jun 7, 2028 | 12 mg | Maintenance Dose (12 mg) | 74.8 kg | -28.8% | GI tolerability & HR monitoring. |
| Wk 87 | Jun 14, 2028 | 12 mg | Maintenance Dose (12 mg) | 74.7 kg | -28.9% | GI tolerability & HR monitoring. |
| Wk 88 | Jun 21, 2028 | 12 mg | Maintenance Dose (12 mg) | 74.5 kg | -29% | GI tolerability & HR monitoring. |
| Wk 89 | Jun 28, 2028 | 12 mg | Maintenance Dose (12 mg) | 74.5 kg | -29% | GI tolerability & HR monitoring. |
| Wk 90 | Jul 5, 2028 | 12 mg | Maintenance Dose (12 mg) | 74.4 kg | -29.1% | GI tolerability & HR monitoring. |
| Wk 91 | Jul 12, 2028 | 12 mg | Maintenance Dose (12 mg) | 74.3 kg | -29.2% | GI tolerability & HR monitoring. |
| Wk 92 | Jul 19, 2028 | 12 mg | Maintenance Dose (12 mg) | 74.2 kg | -29.3% | GI tolerability & HR monitoring. |
| Wk 93 | Jul 26, 2028 | 12 mg | Maintenance Dose (12 mg) | 74.1 kg | -29.4% | GI tolerability & HR monitoring. |
| Wk 94 | Aug 2, 2028 | 12 mg | Maintenance Dose (12 mg) | 74 kg | -29.5% | GI tolerability & HR monitoring. |
| Wk 95 | Aug 9, 2028 | 12 mg | Maintenance Dose (12 mg) | 74 kg | -29.5% | GI tolerability & HR monitoring. |
| Wk 96 | Aug 16, 2028 | 12 mg | Maintenance Dose (12 mg) | 73.9 kg | -29.6% | GI tolerability & HR monitoring. |
| Wk 97 | Aug 23, 2028 | 12 mg | Maintenance Dose (12 mg) | 73.8 kg | -29.7% | GI tolerability & HR monitoring. |
| Wk 98 | Aug 30, 2028 | 12 mg | Maintenance Dose (12 mg) | 73.7 kg | -29.8% | GI tolerability & HR monitoring. |
| Wk 99 | Sep 6, 2028 | 12 mg | Maintenance Dose (12 mg) | 73.6 kg | -29.9% | GI tolerability & HR monitoring. |
| Wk 100 | Sep 13, 2028 | 12 mg | Maintenance Dose (12 mg) | 73.5 kg | -30% | GI tolerability & HR monitoring. |
| Wk 101 | Sep 20, 2028 | 12 mg | Maintenance Dose (12 mg) | 73.5 kg | -30% | GI tolerability & HR monitoring. |
| Wk 102 | Sep 27, 2028 | 12 mg | Maintenance Dose (12 mg) | 73.4 kg | -30.1% | GI tolerability & HR monitoring. |
| Wk 103 | Oct 4, 2028 | 12 mg | Maintenance Dose (12 mg) | 73.3 kg | -30.2% | GI tolerability & HR monitoring. |
| Wk 104 | Oct 11, 2028 | 12 mg | Maintenance Dose (12 mg) | 73.2 kg | -30.3% | Week 104: end of the TRIUMPH-1 extension. Review dose and goals with a doctor. |
| Wk 105 | Oct 18, 2028 | 12 mg | Maintenance Dose (12 mg) | 73.2 kg | -30.3% | GI tolerability & HR monitoring. |
| Wk 106 | Oct 25, 2028 | 12 mg | Maintenance Dose (12 mg) | 73.2 kg | -30.3% | GI tolerability & HR monitoring. |
| Wk 107 | Nov 1, 2028 | 12 mg | Maintenance Dose (12 mg) | 73.2 kg | -30.3% | GI tolerability & HR monitoring. |
| Wk 108 | Nov 8, 2028 | 12 mg | Maintenance Dose (12 mg) | 73.2 kg | -30.3% | Final week of the 108-week plan: scheduled doctor checkup. |